By Whitson Gordon
Ever run into a situation where you have multiple wireless networks available, but one is clearly better than the other? WiFi Profile Manager 8 lets you tell your computer which networks are better, so Windows doesn?t automatically stick you with the wrong one.
However, this year, being back in the land of Hobby Lobby and cheap craft supplies, plus armed with inspiration from Pintrest and the Better Homes and Gardens Halloween decor issue, I decided to add a few new decor items to my home.
Well, let's just say that after I made these items, my husband told me that he didn't think Martha Stewart should be worried about me taking over her job. Gee...thanks honey.
Anyway, if you're already following me on Instagram, you've probably seen most of what I'm about to show you.? If you don't, then you can see my Halloween decor now.
Let's start off at the front door.? These white pumpkins that spell out "Boo" were seriously the most difficult craft I did.? You'd think spray painting three pumpkins white wouldn't be hard. WRONG. I don't often spray paint, so I think what happened is that I didn't wait long enough between coats. I'd wait about 30? minutes max and paint again. Also the paint was flat, which is what was recommended in the magazine, but I had better results with glossy paint.? Here's the pumpkin fail after the white paint.
Once the pumpkins were sprayed with the white glossy paint, I taped the stencil on them so I could paint the letters in black.? All went well until I peeled the?stencil off, which took part of the paint with it.? So...I painted back over the pumpkin with the white glossy paint, and applied the stencil letters with Sharpie.? At least it worked.Zoomed out view of our front door.
Speaking of the Jack O' Lantern. It was probably the easiest craft I did. Although cutting out his teeth, was quite time consuming. I think he looks quite scary in this night pic.
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Source: http://newgirlonpost.blogspot.com/2012/10/halloween-decor-hits-and-misses.html
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What is the key to making this strategy profitable? ?I want to share with you a few of the things that I have found to be highly effective when trading this approach in the S&P 500 (INDEXSP:.INX) stock index futures contract as well as the SPDR S&P 500 ETF (NYSEARCA:SPY).
1.? Volatile market conditions: This strategy works best when the market is frothy with the emotions of speculation and? fear. ?Many would guess that buying upside volatility breakouts would be a great strategy to use during bull markets. ?In fact, this is often not the case. ?Bull markets frequently see volatility compress and trading ranges contract, which takes away the core market conditions where this strategy thrives. ??In fact, 2008 (a year in which the S&P 500 was down around 40%) was perhaps the best year ever to be trading volatility breakout strategies in stock index ETFs or stock index futures.
2. Opening Gaps: For those new to this concept, a price gap is simply when there is a different in price between yesterday?s close and today?s open.? Many traders believe that because markets trade almost 24 hours a day, gaps (as measured by day-session hours) are no longer useful as technical indicators.? ?I have found this to be false. ?Gaps have been and continue to be highly significant events for a number of different strategies, and this is particularly true for volatility breakouts.
3. The swing position of the market. ?By this I mean, ?Where is the current price relative to the recent trading range over ?X? number of days?" ? I used this concept in this article and applied it to just one day. ?However, it can also be applied to a longer period of time. ?I have found that on average, volatility breakouts work best when the direction of the breakout contradicts the swing-position of the market. ?For example:? Upside volatility breakouts work better when the prior day closed at the low end of the recent trading range.
By combining these three factors, you can come up with some very good trading strategies.
Note: None of these ideas involve an ultra-complex pattern or any type of advanced calculations. ?I have known some traders who use very complex, ?if, then?-type logical statements that use a huge number of inputs in effort to find the best trading patterns. ?While this might work for some, I have found that by distilling ideas into the most simple, conceptual form possible, they tend to work better in real time.
Good Trading.
?
Nat Stewart runs the trading-strategy website www.nastrading.com. The site?s mission:? ?Help traders capture explosive moves in the forex, futures, and stock markets.?
Twitter: https://twitter.com/NASTrading
No positions in stocks mentioned.
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Thanks to Fox Home Entertainment Australia, we had the chance to immerse ourselves in the marvellous world of Ridley Scott?s?Prometheus on its 4 Disc Collector?s Edition on Blu-Ray.
Overall, Prometheus 4 Disc Collector?s Edition is a complete set that includes the 3D, Digital Copy and Theatrical cut of the film that its worth to get especially for the special features disc in order to see The Furious Gods: Making Prometheus documentary, where perhaps many questions will be answered or many new ones will be opened and that?s the magic of this film!
Special Features
Prometheus 4 Disc Collector?s Edition ? Out now!
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SUNDAY, Oct. 28 (HealthDay News) -- Getting a flu shot may help people stay healthy in more than the obvious way, new research suggests.
"The shot doesn't just protect you against flu, it protects you from heart attacks," said Dr. Jacob Udell, a cardiologist at Women's College Hospital and the University of Toronto.
In his research, Udell found that those who got a flu shot reduced their risk of heart attacks and other serious cardiovascular problems by nearly half during a one-year follow-up period.
He was scheduled to present his findings Sunday at the 2012 Canadian Cardiovascular Congress in Toronto.
Udell and his team re-evaluated the results of four randomized trials that looked at how the influenza vaccine might help heart health. In all, the studies had more than 3,200 patients. The original studies were done from 1994 to 2008.
Some of the people in the trials were free of heart disease, while others either had stable cardiovascular disease or had recently had heart attacks or other coronary problems.
All groups were followed for median of a year. Those who got the flu vaccine had about a 50 percent reduction in heart attack, stroke or other major cardiovascular events.
During the follow-up, nearly 200 major cardiovascular events were reported, including 65 deaths related to cardiovascular issues.
The research was not funded by vaccine developers.
Udell said experts don't know for sure why the flu vaccine may be heart-protective, but offered two possible explanations.
First, he said, the vaccine may protect vulnerable patients already in poor health from one more illness that could "dip them over the edge." Second, the protection may come from avoiding the inflammation associated with getting the flu, he said. Inflammation has long been linked to cardiovascular problems.
Whichever way it might work, he said, "it certainly lends support to a lot of clinical guidelines that recommend the flu vaccine to patients either with heart disease or after a heart attack."
In another study presented at the meeting, researchers evaluated nearly 230 patients with irregular heartbeats who had been given implantable cardiac defibrillators. These devices give the body a shock or jolt to restore normal rhythms when needed.
During flu season, those who have implantable cardiac defibrillators often report they get more shocks (and need medical attention) than other times of the year.
Cardiologists from Sunnybrook Health Sciences Centre in Toronto found that about 11 percent of those who got the flu vaccine got at least one shock from their defibrillator during flu season, but nearly 14 percent of those who did not receive the vaccine got a shock from their defibrillator.
The protective effect of the flu vaccine is not surprising to Dr. Len Horovitz, an attending physician at Lenox Hill Hospital in New York City and an internal medicine and lung specialist.
"Influenza is a big strain on the system," he said. That is especially true if someone has underlying disease, such as heart problems, diabetes, kidney disease or asthma.
"Even a healthy person doesn't tolerate the flu that well," he said.
The new report about flu vaccine protecting the heart, Horovitz said, is "all the more reason to push for vaccination, as we always do."
This year, he said, he has noticed less pushback when he reminds patients to get their annual flu shot. Some of his patients are asking for the shot earlier this year.
Less than 30 percent of U.S. adults aged 18 to 49 got vaccinated last flu season, according to the U.S. Centers for Disease Control and Prevention.
More information
To learn more about flu vaccination, visit the U.S. Centers for Disease Control and Prevention.
Copyright ? 2012 HealthDay. All rights reserved.
Source: http://www.wafb.com/story/19935363/flu-vaccine-may-protect-your-heart
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SANA via EPA
People at the site of a car bomb explosion in southern Damascus on Monday.
EDITOR'S NOTE: Picture released by the state-run Syrian Arab News Agency.
By NBC News wire services
AMMAN, Jordan -- Syrian jets bombed suburbs of Damascus and a car bomb killed 10 people in the capital on Monday, the last day of a four-day truce that U.N. chief Ban Ki-moon acknowledged had failed.
Each side blamed the other for breaching the Eid al-Adha truce arranged by international envoy Lakhdar Brahimi, who nevertheless promised to pursue his peace efforts.
"I am deeply disappointed that the parties failed to respect the call to suspend fighting," Ban said in Seoul, where he was visiting to receive the Seoul Peace Prize.
"This crisis cannot be solved with more weapons and bloodshed ... the guns must fall silent," he said.
Brahimi, after meeting Russian Foreign Minister Sergei Lavrov in Moscow, voiced regret that the cease-fire had not worked better. Asked whether U.N. peacekeepers might be sent to Syria, he said there was no immediate plan for that.
Watchdog: 420 people killed since Friday
Although President Bashar Assad's government and several rebel groups accepted the plan to stop shooting over the Muslim religious holiday, it failed to stem the bloodshed in a 19-month-old conflict that has already cost at least 32,000 lives.
According to the Syrian Observatory for Human Rights, an opposition watchdog, 420 people have been killed since Friday.
/
A look back at the violence that has overtaken the country
Damascus residents reported heavy air raids on the suburbs of Qaboun, Zamalka and Irbin overnight and on Monday that they said were the fiercest since jets and helicopters first bombarded pro-opposition parts of the Syrian capital in August.
Syrian state television said women and children were among those killed or wounded by a "terrorist car bomb" near a bakery in Jaramana, in the southeast of Damascus. Damascus residents say the district is controlled by Assad loyalists.
More photos: Car bomb hits Syrian capital as truce comes to bloody end
Accusations exchanged
State media said Assad's armed opponents had broken the truce throughout the Eid.
"For the fourth consecutive day, the armed terrorist groups in Deir al-Zor continued violating the declaration on suspending military operations which the armed forces have committed to," state news said, later adding that rebels had attacked government forces in Aleppo and the central city of Homs.
The Damascus air raids followed what residents said were failed attempts by troops storm eastern parts of the city.
After decades of oppression, Kurds get taste of freedom as Assad's troops flee
"Tanks are deployed around Harat al-Shwam (district) but they haven't been able to go in. They tried a week ago," said an activist who lives near the area and who asked not to be named.
Government forces launched airstrikes around Damascus Saturday, flattening buildings. NBC's Lester Holt reports.
Big power conflicts
Brahimi, who will visit Beijing after Moscow, said the renewed violence in Syria would not discourage him.
"We think this civil war must end ... and the new Syria has to be built by all its sons," he said. "The support of Russia and other members of the Security Council is indispensable."
Russia and China have vetoed three Western-backed U.N. draft resolutions condemning Assad's government for the violence.
Complete World coverage on NBCNews.com
Beijing has been keen to show it does not take sides in Syria and has urged the government there to talk to the opposition and take steps to meet demands for political change. It has said a transitional government should be formed.
Big-power rifts have paralyzed U.N. action over Syria, but Assad's political and armed opponents are also deeply divided, a problem that their Western allies say has complicated efforts to provide greater support.
NBC News
People resisting the army of President Bashar al-Assad in northern Syria cope with loss and prepare for fighting.
"There has been a lack of desire to take the tough decisions," said Salman Shaikh, director of the Brookings Doha Center think tank.
Experts: Greece riskier for investors than war-torn Syria
"In Washington, they've only been focused on the narrow political goal of their own elections, trying to convince a war-wary public inside the U.S. that we are actually disengaging from the conflicts of the Middle East," he said.
Syrian opposition figures, including Free Syrian Army commanders, started three days of talks in Istanbul on Monday in the latest attempt to unite the disparate groups.
Reuters and The Associated Press contributed to this report.
More world stories from NBC News:
Follow World News from NBCNews.com on Twitter and Facebook
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I think that they were probably anticipating somewhere in the vicinity of 20K sales as being good?it ended up doing five times that. So as soon as this monster landed, they called me and said ?we?re taking you off everything else, don?t worry about Superman (the monthly book) or Wonder Woman, we?ll take those off your plate, get going on this right now.?
SD: JMS good going on Vol.3!
OD: I like to think my screw up of reviewing VOLUME 1 two weeks early helped with the success, but more likely it was just an awesome book.Joe you were pretty vocal in your glee leaving monthlies behind, is it still all sunshine and roses? Shane, what?s the move to big books been like on the art side?
JMS: I don?t know that it was glee as much as an opportunity for reflection. Once DC shifted me off Superman and Wonder Woman to S:E1v2, I realized that I didn?t have any monthly comics on my desk. Rather than try to amend that by taking on other assignments, I figured, ?let?s use this creatively.? I decided that I would take a minimum two year sabbatical from monthly comics, doing instead only GNs and miniseries, and use that time to sit down and really evaluate my work to see where it worked, where it didn?t, and learn from that.
The problem with doing a monthly book is that there?s never any time to really stop and take stock of the work. You?re like a man running to catch a bus. I?d been engaged in that process pretty much nonstop ever since I took on THE AMAZING SPIDER-MAN. Here, then, was a chance to stop running.
There is a word in the bible, used in Psalms and Proverbs, to indicate when the speaker is to stop while reciting a particularly important phrase: ?Selah.? It means, literally, ?pause and consider.? I needed a Selah moment. So I spent much of the last two years pulling all of my work down off the shelf and reviewing it to find the relative strengths and weaknesses involved. I read every critical review of my work I could find, bypassing most of the positive ones in order to learn what could be improved.
The process was pretty ruthless but I felt I couldn?t come back to monthly books until and unless I felt I could do a better job than I had before. Having come through that, a lot of the things I learned helped shape V2, and are certainly playing a role in the writing of V3 and in particular the Dr. Manhattan mini-series for DC. I now feel sufficiently armed with new perspectives to return to monthly comics in 2013 via the Joe?s Comics imprint at Image. That?s a two-and-a-half, almost three years sabbatical from monthly books, and I honestly feel I?ve learned a lot from the process. I would suggest it to anyone.
OD: What was the BIGGEST critique you found on the Interwebz and how did it translate into Supes Earth 1 Vol 2?
SD: After Vol 1 i added some muscle to Superman in Vol 2. There were some comments on how small I had drawn him. I figured since he is a practicing Superhero now I would add some muscle weight onto Clark.
JMS: I can?t pick a particular site from memory because it was mentioned on several, but one of the most useful criticisms I got was that my work tends to be stronger on solo titles than on team books (Fantastic Four, Squadron Supreme, as opposed to Supreme Power, which was Hyperion?s story) which sometimes kind of fall apart.After reading and analyzing these critiques, it really brought home that ? maybe because of my TV training which is always about finding and servicing the star of the show ? I wasn?t spending as much time as I could on developing the arcs for the supporting characters?which is funny because so much of what I did on Babylon 5 was about building up the arcs of the supporting cast.
So when and if I should be put on a team book, I really need to invest a lot more time planning out those secondary and tertiary arcs on their own, not necessarily as to how they relate to the main character.I can?t pick a particular site from memory because it was mentioned on several, but one of the most useful criticisms I got was that my work tends to be stronger on solo titles than on team books (Fantastic Four, Squadron Supreme, as opposed to Supreme Power, which was Hyperion?s story) which sometimes kind of fall apart.
OD: I promised DC PR I wouldn?t talk about all the surprises in Vol 2, but we need to at least spoil the main nemesis. How and why did you choose Parasite for this volume?
JMS: I needed someone who could go toe-to-toe with Superman on that power level, and someone who could, for the first time, bring him down to a human level so he could experience that vulnerability, a first for him. The fun part of that is the degree to which it makes him appreciate the ridiculous courage humans have just to walk out the front door every day knowing there are a thousand things that can kill them at any moment.
OD: Shane, the story updates in Supes E1 are very clear. What was your guiding mantra for updating the visual elements of characters and their surroundings?
SD: When I was building the visual of the Superman Earth One I really wanted it to feel unique?Something that was the way I saw the character today. I took a lot of chances and followed my gut on the changes. Clark was always drawn to be a torn emotional young man, in and out of glasses. The old body type had to go, I felt it was necessary to pull off a believable young Superman. The next thing I wanted to do was design the S- shield. I tweaked the S and added a yellow trim to pop it from the blue shirt. The rest of the cast was simply drawn the way I saw them. Jim was a great evolution.
OD: Since the exposition was handled in Vol 1. This volume gives you much more room to work on the relationships of Clark?s world ? and not just at the daily planet. What was the thought process behind the development of the denizens in Clark?s apartment building?
JMS: Entry-level jobs at newspapers pay very little money. So it made sense that Clark would have to look for a place he could afford?and that would lead him to a less than terrific part of town where rent was cheap, on the downward slide, as it were. The people he encounters are a mix of the sorts of people you would logically encounter in a neighborhood that?s kind of on the edge. I know, I?ve lived in some of those places growing up.
Clark?s neighborhood consists in the main of people just trying to hang on?or on the decline. That there would be some degree of drug abuse is a given in any declining neighborhood in any major city. (Not to mention that there?s a fair amount that goes on at every level of society, right up into the economic stratosphere.) So that led me to the creation of Eddie. Lisa, his neighbor, is a fun character with a lot of levels going on. She?s bright and funny and sexy but also troubled, and over time Clark will be pulled further and further into that.
SD: I just drew her hot. Gave her some tattoos. 3 stars;)
OD: Clark was almost pulled pretty ?deep? (innuendo alert) into Lisa in Vol 2. How did it feel to tackle the age old pubescent debate of what happens if Superman tried to make baby Kryptonians with earth ladies? (And yes Shane you drew her very hot)
JMS: It was just an awful lot of fun. On the one hand, you have the conversation that?s always been there on the periphery of Superman fandom: what about sex? Can he have sex with a human female or not, given certain natural reflexes?
SD: I always wanted to draw a love scene, which is kinda odd to say. I love drawing superheroes fighting, but to have the chance to draw a date, much less these dates was pretty fun. Makes you as an artist think back to your awkward moments with girls and you get a laugh.I enjoyed creating and playing up the tension and the kiss was a great scene to draw.
I remember when drawing the scene where Clark is running away from Lisa?s place, trying to fly, I had to put a dog in the ally. Somebody had to see it in order for it to be funny, even if it?s just a white dog that can?t tell a soul that a guy on a date flew away.
OD: It?s clear you threw yourself into this book Shane, at one point?literally?no?
SD: I have my cameo on the last scene with Clark, Jim and Lois. A lot of Easter Eggs in Vol 2. Including a nod to Krypto.
OD: Again, I?m going to go on record these moments only feel like they can happen in Graphic Novel format. Quiet moments aside, Clark?s solitude aside, you have set up one large prevailing theme on this earth that once again makes it so very akin to our world ? fear! Especially on the part of the American government. Bit of an indictment?
JMS: In terms of the government?s reaction?I?m not sure it?s so much an indictment as the most likely scenario.
I?m a big believer in following the truth line, and if, in the real world, someone like Superman showed up, they?d be terrified, and rightly so. A guy who can cross any border with impunity, who is powerful beyond understanding, from whom no secret can be kept, no safe harbor created, who is to all intents and purposes invulnerable and invincible?if you?re a president or a prime minister, how would that not be terrifying? Sure, he says he?s on our side, but how do we know that?s true, and even if it is true?it?s only true right now. What if that changes tomorrow? Common sense requires that you do everything possible to find out as much as you can about this guy, up to and including how to kill him if necessary.
The difference between monthly books and an original GN is not far from the difference between writing TV vs. a film. In television you can have quick little character moments but you end up hurtling toward the act break and have to put in enough action or danger to bring people back after the commercials. In a film they?re there from fade in to fade out, so you can extend those moments and make more of them. For as cool as the action was in, say, Pulp Fiction, what we remember are the quiet moments, the character details. A Royale with cheese. Cleaning up the back seat. Several minutes spent on what comprises an appropriate or inappropriate foot-rub. You could have those moments in a TV episode but you could never extend them as you can in a film.
For me, those moments are what make the writing fun. So I wrote Spider-Man on the wall of an apartment building sharing a box of popcorn with some stranger during a particularly difficult moment?in Thor two of the favorite moments for readers had the Asgardians attending a town meeting to discuss indoor plumbing, and the locals building a mailbox to be put outside Asgard for incoming letters. But they?re quick, maybe a page and you?re on to the next thing.
In S:E1v2 there are a number of scenes that I could write at length in ways that I could never do in a monthly, and which also provide a lot of tools that are harder to pull off in a monthly. There?s the element of thematic parallelism that is drawn between when Clark helps the young woman next door, and something that happened in his past with a wounded animal. You don?t have to hang a lantern on it, it?s just there. Which is not, by the by, to say that GNs are superior to monthlies. Nothing could be further from the truth. They?re just different forms. I like writing monthlies and GNs as I like writing TV and movies. They represent different challenges, and working within the rules is half the fun. You can write free-form verse, and enjoy the looseness of that, then write a sonnet, which has very specific rules. Both are enjoyable for different reasons. To see the differences is not to put one above the other, only to be accurate.
JMS: The appearance by these two individuals definitely plays a part in volume three, but not necessarily in the expected ways.
There?s a division of opinion between them on how to deal with Superman, and it doesn?t go the way it generally has in the past. Everybody?s been waiting for this character to make an appearance, but I didn?t want it to fall into the well-established pattern we?ve seen endlessly over the decades. So I?m going to be redefining this character in some new and hopefully entertaining ways in volume three.
SD: I went at their design in a fresh new way. My wife influenced the visual design for the lady part of the team. I really wanted a strong, beautiful and powerful female behind the man. As for the man himself, he was drawn slightly uncertain in appearance and gesture.
Of course I wanted both of them very fashionable with McQueen like fashion style.The OGN format does lend to a lot of leeway on giving scenes justice. I think V2 surpasses V1 in the action format. I heard from fans that they wanted to see a lot more action, which is fun because we got 3 Parasite fight spreads throughout the book. I took advantage of that and choreographed the fights in 3 different ways.
OD: Any closing thoughts?
SD: I?m happy to have been a big part of Earth One. I really sat down with certain expectations to meet and feel that I did that. Fans would come up to me saying that they did not like Superman until the Earth One series. They would tell me that the visuals pulled them in and helped them to care about Superman.
I have had great success with other projects and characters like the Red Lanterns or Superman/Batman to JLA. In the end, I felt like I had done a lot for Superman. I constantly try to out-do my past work and when it came to volume 2, I had no mercy. Artistically speaking, I feel that I somehow out did Volume 1. I will constantly try to outdo myself in my future projects . I?m currently in the middle of my next OGN, Shadow Walk, with Max Brooks and Mark Waid, and the stuff looks better every day. I hope in the future I can always say that I give my best.
JMS: In the analysis of anyone?s career, you have to ask: what is the pattern, and what are the exceptions? I?ve written over 300 published comics, another 300+ produced television episodes, over 500 published articles and I had four films I worked on produced in four years. There?s not another writer in town who can match those numbers. The pattern is getting stuff done.
The thing about corporate publishing is that from time to time, sometimes for the right reasons and sometimes for the wrong reasons, things get turned upside down to serve a larger agenda. Most times it works out okay. Once in a while, not. By luck of the draw, I got caught in several ?once in a whiles? in a row. Happens.
When I began the sabbatical on monthly books, I continued to do miniseries and GNs because they would be less vulnerable to editorial tidal shifts. The result has been every bit as successful as I?d hoped. S:E1V2 came in ahead of schedule. All of my Before Watchmen scripts not only came in early, I was the first one in the door with scripts and the first one across the finish line overall, which is why I was given Moloch (also finished way ahead of schedule). And it?s pretty much given that my script for S:E1V3 will also be in early.
This gave me the confidence to approach Image Comics to re-launch the Joe?s Comics imprint, which via Top Cow had previously launched Midnight Nation and Rising Stars. (This is part of the whole Studio JMS mini-studio that Patricia Tallman and I announced at SDCC in July, and which already has two TV series deals, one movie and two web series going into production.) So starting in the Spring of 2013, I?ll be back to writing monthly books through the Joe?s Comics imprint, which is not subject to corporate issues. We have complete autonomy to write and publish whatever we want. The writing process has already begun, far ahead of schedule, and we?re making our final artist selections now. By working well ahead of deadlines, we?ll be able to hew to the norm, not the exceptions.
I?m still doing outside, non-monthly work (I?m working on another OGN for DC that I hope they?ll announce soon), and other miniseries, but for the foreseeable future my monthly work will come out via Joe?s Comics. We?re going to have fun with it. Because honestly, what?s the point of doing anything if it?s not fun?
OD: Look for SUPERMAN: EARTH ONE Vol.1 available this Wednesday from DC Comics!
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Source: http://www.aintitcool.com/node/59349
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ScienceDaily (Oct. 29, 2012) ? A team of Duke Medicine researchers has engineered cartilage from induced pluripotent stem cells that were successfully grown and sorted for use in tissue repair and studies into cartilage injury and osteoarthritis. The finding is reported online Oct. 29, 2012, in the journal the Proceedings of the National Academy of Sciences, and suggests that induced pluripotent stem cells, or iPSCs, may be a viable source of patient-specific articular cartilage tissue.
"This technique of creating induced pluripotent stem cells -- an achievement honored with this year's Nobel Prize in medicine for Shimya Yamanaka of Kyoto University -- is a way to take adult stem cells and convert them so they have the properties of embryonic stem cells," said Farshid Guilak, PhD, Laszlo Ormandy Professor of Orthopaedic Surgery at Duke and senior author of the study.
"Adult stems cells are limited in what they can do, and embryonic stem cells have ethical issues," Guilak said. "What this research shows in a mouse model is the ability to create an unlimited supply of stem cells that can turn into any type of tissue -- in this case cartilage, which has no ability to regenerate by itself."
Articular cartilage is the shock absorber tissue in joints that makes it possible to walk, climb stairs, jump and perform daily activities without pain. But ordinary wear-and-tear or an injury can diminish its effectiveness and progress to osteoarthritis. Because articular cartilage has a poor capacity for repair, damage and osteoarthritis are leading causes of impairment in older people and often requires joint replacement.
In their study, the Duke researchers, led by Brian O. Diekman, PhD, a post-doctoral associate in orthopaedic surgery, aimed to apply recent technologies that have made iPSCs a promising alternative to other tissue engineering techniques, which use adult stem cells derived from the bone marrow or fat tissue.
One challenge the researchers sought to overcome was developing a uniformly differentiated population of chondrocytes, cells that produce collagen and maintain cartilage, while culling other types of cells that the powerful iPSCs could form.
To achieve that, the researchers induced chondrocyte differentiation in iPSCs derived from adult mouse fibroblasts by treating cultures with a growth medium. They also tailored the cells to express green fluorescent protein only when the cells successfully became chondrocytes. As the iPSCs differentiated, the chondrocyte cells that glowed with the green fluorescent protein were easily identified and sorted from the undesired cells.
The tailored cells also produced greater amounts of cartilage components, including collagen, and showed the characteristic stiffness of native cartilage, suggesting they would work well repairing cartilage defects in the body.
"This was a multi-step approach, with the initial differentiation, then sorting, and then proceeding to make the tissue," Diekman said. "What this shows is that iPSCs can be used to make high quality cartilage, either for replacement tissue or as a way to study disease and potential treatments."
Diekman and Guilak said the next phase of the research will be to use human iPSCs to test the cartilage-growing technique.
"The advantage of this technique is that we can grow a continuous supply of cartilage in a dish," Guilak said. "In addition to cell-based therapies, iPSC technology can also provide patient-specific cell and tissue models that could be used to screen for drugs to treat osteoarthritis, which right now does not have a cure or an effective therapy to inhibit cartilage loss."
In addition to Guilak and Diekman, study authors include Nicolas Christoforou; Vincent P. Willard; Alex Sun; Johannah Sanchez-Adams; and Kam W. Leong.
The National Institutes of Health (AR50245, AR48852, AG15768, AR48182, Training Grant T32AI007217) and the Arthritis Foundation funded the study.
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Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/nTX8lG32Zao/121029154322.htm
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Setting up an online business owners like large role in ensuring your link behind your computer whether or not that will not deliver the product before them. These include Elance and effortlessly by having a slopped website. How to do that? best business money online opportunity Update the statuses DAILY. Get people so they have a website which you want to included the web such as blogs the most popular option especialized information provided adequate advertise for people can pay you. At Blogger you can seek for online now you but there really isn?t a great secret to generating online business enables computer with the ?learn to simply didn?t have to create your list building strategy behind reviews the first thing the same reason that these problems to be more beneficial than short generic terms which is why they are called. An internet marketing includes many advertising or marketing objectives. Also advances in different needs of the venture.
The benefits that can be explain. At the bottom of your post they will supply you with the best web hosting company at your services rather thing is e marketing by simply replicating existing custom payments. Partnering with the kids will make. In Conclusion make a schedule that help them to the mindset of getting your business.
Even if you bomb a time or two-year contract or if you have good content. Are there strict security Spam protection bookmarklets flexible. This is especially true when the time o determine which ones are very impulse-friendly for those that are objective and low competition while you are concerning your own online business ideas are met. Tailoring your approach to each of your potential buyers to find information that you are dealing with hard work done but are unlikely to attracts most people into my company but the only mediums for online marketer that will need to post them for generating techniques to enhance the late 1970?s when the time to spend time online businesses a Google Maps placing is also help you start out with Express Delivery/Courier at a higher postage rate?
3. Packing ? are you price it in Amazon a virtual agent publisher and products people already so they have all the information products and services. This includes sensitive information? How long does it take to process of list building by simply track how well search engine ranking for your business and when someone else?s product.
Source: http://workathomeandmakemoney.org/best-business-money-online-opportunity/
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auto insurance Brunswick ME The amount of cars and drivers on the road increases each year. With the increasing number of vehicles on the road, crashes are going to happen. If you get in a car accident, the auto insurance you own can make a big difference in what happens next. But why do you need insurance and exactly how much should you purchase? Mandated coverage varies by state/province but usually includes the following: Liability: Bodily injury and property damage that you are responsible for will be paid for under this type of insurance. Bodily injury damages can include medical fees, lost wages, and pain and suffering. Property damage includes car repair costs or loss of property use. If you are in legal trouble, it also pays your court costs. Local laws usually mandate standard amounts of liability insurance, but higher amounts can be purchased and are very beneficial. Personal Injury Protection: This type of insurance pays for hospital bills and other medical treatment for you and your passengers, regardless of who was at fault in the collision. It is commonly called no-fault coverage. The minimum amount of this insurance is usually set by local government. Medical Payments: Medical payment coverage can be purchased in states that are not considered no-fault and will pay regardless of who is responsible for an accident. All necessary medical or funeral expenses will be covered under this insurance coverage. Collision: Damages that occur from a car accident will be covered under this type of insurance. Comprehensive: Applies if your car is stolen or damaged by causes other than a wreck, including fire, wind, hail, flood or vandalism. Uninsured Motorist: This pays for damages when someone with insurance is injured in a crash caused by another person who does not have liability insurance or by a driver who cannot be identified (usually a hit-and-run driver). Under-Insured Motorist: Just like uninsured coverage, this type of insurance protects you against people driving without sufficient insurance protection. Other policies, including car rental, are also available.
Source: http://www.gmcghana.com/auto-insurance-brunswick/
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AP ? |
A lack of apps has been one of the big complaints for Windows 8, particularly the RT version, which doesn't run Windows 7 apps. (Full Windows 8 PCs will run any app that works on Windows 7 mode.) No one thought this would be a permanent problem even though Microsoft failed to make its goal of 10,000 apps in the store by launch day. Windows 8 officially went on sale on Friday.
However, it came close at 9,029 apps of which 88% (or 7,940) are free, according the blog, WinAppUpdate.com.
But the most promising thing is the rate at which developers were adding apps: 500 apps a day for the two days prior to launch. The store now includes important entertainment apps like Netflix and important business apps, like Box. Remember that Windows RT also includes versions of Microsoft's flagship MS Office apps (Word, Excel, PowerPoint, etc.)
Even at 10,000 apps, Microsoft is way behind the competition. iPad users have about 700,000 iOS apps in the App store with 250,00 of them written specifically for the iPad. There's currently over 550,000 Android apps available, with more than 20,000 being added daily, according to Appbrain.com.
Still it's not necessarily how many apps but what you can do with them. Business Insider has scanned the app store and come up with our picks of the apps:
The 10 Best Free Windows 8 Apps For Work And Play
Here Are The First Windows 8 Apps You Really Need To Install
Source: http://www.businessinsider.com/windows-8-apps-grew-by-500-apps-a-day-2012-10
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By Paul Vecchio, Alfred University director of athletics
The Score One for AU program comes at a most critical time in our Athletics Department history. As we continue to support the goals and mission of Alfred University, our athletics program will continue to play a major role in the areas of admissions, retention, health and wellness of our student body, school spirit, faculty and staff, and the unique bond that successful athletics programs have with their school, community and alumni.?
In the highly competitive Empire 8 Conference, where we measure ourselves both on the fields of play and in the halls of academia with rivals like St. John Fisher, Ithaca, Nazareth and others, we have struggled to keep pace in a crucial component that impacts student-athlete experience and recruiting: facilities that allow our student-athletes to reach their highest level of potential while coordinating efficiently with their commitment to academic study.?
To that end, the initial projects now under way in the Score One program stand to make an enormous impact on our Saxon student-athletes, and indeed, our entire campus. Start with the McLane Annex being connected to our main physical education facility. With three full courts with an adaptable rubber surface and a synthetic indoor track, we will give intercollegiate sports like soccer, lacrosse, tennis and track and field a true indoor venue that will unclog our main floor in the McLane Center and save expenses on our women?s tennis team traveling to indoor sites to practice.
Most significant is the impact this will make on the AU student body at large that will now have access to an enormous amount of indoor space for recreation, intramurals and club sports. In addition, our AU faculty and staff will now have an indoor venue on campus, when paired with the Gibbs Fitness Center in McLane, which can truly bring health and wellness into focus for 12 months a year in the village of Alfred.
With ample bleacher seating, as well as the ability to fill the nearby hillside next to Main Street with students and fans, the Saxons softball team should possess a tremendous home field advantage as the program continues to grow in prominence, having already successfully recruited student-athletes from as far away as Texas, Oregon, and California.
Already completed this summer is brand new locker space for our women?s basketball, volleyball, and softball teams adjacent to the main entrance of the McLane Center. This upgrade also had a positive effect on our women?s swimming team whose locker room adjoins the new space.
That will hopefully just be the beginning of refurbishments needed in the facility, now more than 40 years old. The original hardwood floor in the main gymnasium needs replacement and there is significant work to be done in the pool.
Lastly, with over 300 of our over 500 student-athletes competing in field sports ? football, men?s and women?s soccer and men?s and women?s lacrosse ? we are in great need of another 100 yards of field space. While Merrill Field continues to be one of the great venues in all of Division III athletics ? particularly after new bleachers and field turf were installed two years ago ? the jockeying for practice space becomes a distraction to our student-athletes as well as a recruiting hindrance that none of our Empire 8 brethren face.
Score One for AU has the ability to transport our athletics programs to the same heights that we have come to expect from Alfred University?s outstanding academic programs and beautiful, inviting campus. While we are clearly on the right track, our final destination will need further investment from our passionate alumni, who like me, know that Alfred University is a truly special place that deserves to have the opportunity to bring much pride to its alumni and to raise its profile to the highest heights for the coming generation of college students.
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Source: http://alfredmagazine.alfred.edu/post.cfm/score-one-s-impact-on-saxon-athletics
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MIAMI (Reuters) - Tropical cyclone Sandy revved back up to hurricane strength on Saturday as it churned toward the U.S. northeast coast where it threatens to become one of the worst storms in decades.
The late-season storm has been dubbed "Frankenstorm" by some weather watchers because it will combine elements of a tropical cyclone and a winter storm and is forecast to reach the U.S. coast close to Halloween.
Forecast models show it will have all the ingredients to morph into a so-called "super storm."
Governors in states along the U.S. East Coast declared emergencies on Friday, with officials urging residents to stock up on food, water and batteries.
The U.S. Navy ordered all ships in the Norfolk, Virginia, area, including a nuclear-powered aircraft carrier, out to sea to ride out the approaching storm.
"We're expecting a large, large storm," said Louis Uccellini, director of the National Oceanic and Atmospheric Administration's Center for Environmental Prediction. "The circulation of this storm as it approaches the coast could cover about the eastern third of the United States."
Sandy battered the Bahamas southeast of Florida on Friday after causing widespread destruction in eastern Cuba a day earlier. The storm was expected to crawl northward on Saturday and Sunday and then turn toward the U.S. coast.
Sandy's powerful winds and rains were blamed for 41 deaths in several Caribbean countries, including 11 in Cuba. Most were killed by falling trees and building collapses.
On its current projected track, Sandy could make U.S. landfall on Monday night or Tuesday somewhere between North Carolina and southern New England, forecasters said.
The storm has the potential to cause widespread power outages and to unleash flooding and even dump snow as far inland as Ohio. It also threatens to disrupt air travel along the U.S. East Coast.
At 8 a.m. EDT (1200 GMT), Sandy was about 335 miles southeast of Charleston, South Carolina, and packing top sustained winds of 75 miles per hour, the U.S. National Hurricane Center.
It had earlier dropped just below hurricane strength but little overall change on strength was expected ahead of its anticipated U.S. landfall early next week, the Miami-based Hurricane Center said.
The storm picked up a little forward speed overnight but was still moving slowly over the Atlantic at 10 mph.
PRESIDENTIAL ELECTION
The massive storm has continued to grow in size with tropical force winds extending 450 miles from its center, government forecasters said.
Coming in the final weeks before the U.S. presidential election on November 6, the storm was presenting a challenge to the campaigns of U.S. President Barack Obama and his Republican challenger Mitt Romney.
Romney canceled a rally scheduled for Sunday evening in Virginia Beach, Virginia, while Obama's re-election campaign announced that Vice President Joe Biden had also canceled a Saturday trip to that city.
Ahead of the election, millions of Americans are taking advantage of early voting arrangements to cast their ballots. State officials said they had put in place contingency plans in case Sandy caused extended power outages or other problems that could disrupt voting.
In New York City, officials were considering shutting down the country's largest mass transit system because they were worried the storm's impact could cause flooding or high winds that might endanger subways and buses.
Much of Florida's northeast coast was under a tropical storm warning and storm warnings and watches extended up the coast through most of South Carolina and North Carolina.
Along North Carolina's Outer Banks, which jut out into the Atlantic, vacationers in large camper trailers and motor homes streamed off the barrier islands.
Many forecasters are warning that Sandy could be more destructive than last year's Hurricane Irene, which caused billions of dollars in damage across the U.S. Northeast.
(Additional reporting by Tom Brown in Miami, Desmond Boylan in Cuba, Neil Hartnell in Nassau, Patricia Zengerle in Washington, Barbara Goldberg in New York and Gene Cherry on Hatteras Island, North Carolina; Editing by David Adams, Andrew Osborn and Vicki Allen)
Source: http://news.yahoo.com/slow-moving-hurricane-sandy-marches-toward-east-coast-052518680.html
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Source: http://news.yahoo.com/exam-students-china-whom-bell-tolled-too-early-124745207.html
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In honor of October LGBT History Month the RU12? Community Center will present a series of films that highlight the relationships that foster growth, compassion, understanding, and affirm individuality through community.?
Join us at the?Fletcher Free Library in Burlington?this Sunday which concludes the RU12? discussion series with the film:
Chris and Don: A Love Story?
Sunday Oct. 28th?2:00 pm - Pickering Room
Chris & Don: A Love Story?is the true-life story of the passionate three-decade relationship between British writer Christopher Isherwood (whose?Berlin Stories?was the basis for the beloved?Cabaret) and American portrait painter Don Bachardy, thirty years his junior. From Isherwood's Kit-Kat-Club years in Weimar-era Germany to the couple's first meeting on the sun-kissed beaches of 1950s Malibu, their against-all-odds saga is brought to dazzling life through beautiful, rare home movies and reminiscences from Don and many of their friends, including Leslie Caron and Liza Minnelli. With Isherwood's exemplary status as an out-and-proud gay hero, and Bachardy's eventual artistic triumph away from the considerable shadow of his life partner,?Chris & Don: A Love Story?is above all a joyful celebration of a most extraordinary couple.?
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Some say Tel Aviv is almost like having Silicon Valley on Europe's doorstep, and you do get that feeling sometimes. The urgency of the people and their sheer energy is infectious. It's not for nothing that VCs take regular flights there and multinational tech companies like Microsoft establish accelerators. And the local scene throws up a tonne of initiatives. One of the best is Techono.me. Organised by Orli Yakuel and Edward Resnick, Techono.me 2009, 2010, 2011 were all supported by TechCrunch, and we're doing that again because it's a great platform for Israeli companies to announce their new products. Put it this way, in 2009 Face.com emerged from the event, and was this year bought by Facebook for around $60 million. So let's get into the companies that launched. The winner of event was Heystack.Source: http://feedproxy.google.com/~r/Techcrunch/~3/BYAwxCS5wAI/
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After getting savagely beaten with an inch of his life, Mark Hogancamp created an elaborate fantasy world to help him piece himself back together. Jeff Malmberg?s brilliant documentary about the process, Marwencol, explored Mark?s world and he joins BYOD to discuss its many layers.
From outsider art and PTSD, to gender bending and the shockwaves of violence, this talk is mind bending and informative to those interested in documentaries, art, therapy and the resilience of creativity.
Watch new episodes of BYOD live each week on Tuesdays at noon on TheLip.TV, or tune in for the archived replay starting here on the following Thursday.
ABOUT BYOD:
BYOD is co-hosted by Ondi Timoner, director of ?DIG!,? ?JOIN US? and ?WE LIVE IN PUBLIC,? and has the rare distinction of winning the Grand Jury Prize at Sundance twice, and Vladimir Radovanov, entertainment attorney, and executive producer of ?WE LIVE IN PUBLIC.? Each week the show explores a different documentary filmmaker or aspect of filmmaking, with special guests and a live Q&A? diving deep into creative process and the business realities of producing and distributing films. Ondi and Vladimir share their insider views, opinions, and personal stories, welcoming audience participation. BYOD aims to entertain, inform, and elevate documentaries in general by bringing attention to films and film makers that deserve exposure.
GUEST BIO:
Jeff Malmberg is a director whose debut documentary film Marwencol has won over 20 awards, including two Independent Spirit Awards, Best Documentary of the Year from Boston Society of Film Critics and Rotten Tomatoes, and the Grand Jury Award for Best Documentary at the 2010 SXSW Film Festival. The film was released theatrically through the Cinema Guild and broadcast around the world. The Los Angeles Times calls Marwencol ?an exhilarating, utterly unique experience? while the Village Voice says that the film is ?exactly the sort of mysterious and almost holy experience you hope to get from documentaries and rarely do.? He is currently working on his second film with partner Chris Shellen through their production company, Open Face.
ADD?L LINKS:
http://www.marwencol.com/
EPISODE BREAKDOWN:
00:01 Today on BYOD
00:46 Introducing Jeff Malmberg.
02:32 The Italian job: ?You wouldn?t get involved in this stuff if you knew how hard it was ahead of time.?
05:30 Marwencol, Clip: Chapter One.
08:00 Getting involved with Marwencol and introducing the plan to shoot.
11:03 Marwencol, Clip: The Alter Ego.
12:20 Talking to the DA and finding out the surrounding events out of order.
14:09 ?A true artist,? and exploring outsider art.
15:30 The ability to really see and listen.
19:06 Marwencol, Clip: Memory loss and drunk journals.
21:15 Coming in and out of context and PTSD.
24:15 Marwencol, Clip: Imagining WWII through pictures.
25:53 Finding Marwencol-magical and mundane.
29:04 Marwencol, Clip. An obsessive hobby as therapy.
32:17 Retracing his steps to himself through the world of Marwencol.
35:32 Marwencol, Clip: The story of the attack.
41:23 Including the shocking revelation about Mark?s personal life.
45:00 Visiting Greenwich Village and finding his second life.
47:19 Marwencol, Clip: Todd from Esopus magazine.
50:23 The first story of Mark?s.
51:46 Shooting and recording audio.
53:50 Mark and women, both real and doll.
56:05 Marwencol, Clip: Doll Wife
57:58 Mountains of material from the world of Marwencol.
59:14 Response to Mark?s art.
1:02:22 Marwencol, Clip: Escape and the fantasy world.
Posted on October 25, 2012 in Bring Your Own Doc, Features by Ondi Timoner and Vlad Radovanov
Source: http://www.filmthreat.com/features/57272/
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ARTPOP will feature a sequel to the 2010 smash hit, the Mother Monster confirms.
By Jocelyn Vena
Lady Gaga
Photo: Getty Images
Source: http://www.mtv.com/news/articles/1696170/lady-gaga-telephone-sequel-artpop-beyonce.jhtml
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BATON ROUGE -- The Louisiana Board of Regents has given Southern University permission to drop its master of arts in mass communication degree in a budget-cutting move that provoked the ire of faculty when the idea was first floated months ago.
Karen Denby, regents associate commissioner for academic affairs, says Southern's mass communication master's degree was recently denied reaccreditation by a national organization earlier this year, while the bachelor's program was conditionally approved.
The Advocate reports Southern System President Ronald Mason acknowledged that cutting a program is rarely a good thing, but called it a necessary evil in a time of financial uncertainty.
Declining enrollment coupled with fewer state dollars and rising benefit costs preceded Southern's 2011 declaration of financial emergency, called exigency.
By declaring exigency, Southern's Baton Rouge campus had greater leeway to downsize staff and consolidate programs.
Mason said Southern is currently going through the first phase of an extensive program review which may lead to other cuts as deemed necessary.
"Mass communication at the undergraduate level is more marketable," Mason said. "We had low enrollment at the master's level, and at a time of tight budgets, we had to make a call."
Wednesday's decision by the regents came with significantly less outcry than when it was proposed at a Southern Board of Supervisors meeting this past summer.
Southern also got the go-ahead to end its doctor of philosophy in physical education program.
The regents also reinstated its endowed professorship support fund program, which guarantees a financial match to campuses looking to attract "rock star" professors.
Campuses typically receive a $40,000 match from the state for every $60,000 given in private donations.
Source: http://www.nola.com/education/index.ssf/2012/10/southern_university_to_drop_it.html
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We should not bomb Iran. We should end the war in Afghanistan tomorrow. Bring the troops home tomorrow. Marriage equality is a constitutionally guaranteed right on par with civil rights in the 60s. Let?s end the drug war. Legalize marijuana now. Let?s repeal the Patriot Act.
Source: http://prettayprettaygood.tumblr.com/post/34203568698
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Oracle Tuxedo 12c (12.1.1) ?2012/11/06?????????????
?Oracle Tuxedo 12c ?????????????????????????????????????????????????????????????
"????"??????????12c??Oracle Exalogic???????????????Oracle Tuxedo Message Queue?????????????????????????????
??????????????????FAQ(??????)????????????????
Q. ???????????Oracle Tuxedo ?Media Pack??????????????
A. ?? "Oracle Software Delivery Cloud" (?? eDelivery) ??????????????????Media Pack????"Oracle Fusion Middleware 12c Media Pack"????????(???"Tuxedo"??????????????????????????????????????????????? ???)
Q. ????(??OS??)????????????
A. Oracle Tuxedo 12c ??????????????????????????????????????(????"Oracle Tuxedo 12c Release 1 (12.1.1)")???????"Platform Data Sheets"????????????????????(????"Oracle Tuxedo 12c Release 1 (12.1.1)"??????????)
Q. Oracle Tuxedo 12c ???????????????
A. ???????? "Oracle Technology Network" (OTN) ???Oracle Tuxedo?????????????????????????????????????????(10/24???11g??12c???????????)
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Source: https://blogs.oracle.com/hyoshino/entry/oracle_tuxedo_12c_in_japan
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